Development of Biomimetic Nano/Micro Platforms for Hematopoietic Stem Cell Expansion and Engraftment
Develop integrated nano/micro platforms for hematopoietic stem cell expansion and therapeutic delivery, utilizing biomimetic 3D scaffolds, controlled growth factor release, and injectable hydrogels to enhance HSC engraftment and bone regeneration for clinical applications in hematologic disease treatment
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Engineering 3D co-culture systems with controlled protein/gene delivery for HSC expansion from cord blood and peripheral blood
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Developing surface-modified biomaterials integrated with growth factor-loaded microparticles and embryonic stem cell spheroids
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Creating bone-mimetic nano/microfiber scaffolds with sustained release capabilities for bone regeneration
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Establishing microfluidic culture systems to optimize cell-cell and cell-biomolecule interactions
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Designing injectable hydrogel composites with tunable mechanical properties for enhanced HSC engraftment in bone marrow