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Engineering Functional Microparticles to Modulate Bone Marrow–Like Microenvironments for Hematopoietic Stem Cell Regulation
Develop a scalable and modular culture system using surface-engineered gelatin microparticles (GMPs) to mimic key biophysical cues of the bone marrow niche, enabling enhanced survival and enucleationof hematopoietic stem cells (HSCs).
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Engineering functional GMPs with positive surface charge or mineral coatings to recreate bone marrow–like microenvironments and modulate HSC behavior
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Enhancing erythroid enucleation via electrostatic interactions between HSCs and surface-modified microparticles
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Designing a scalable GMP production platform using a piezoelectric microdroplet system for future clinical translation and magnetic recovery
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