Development of Patient-Specific Multi-Cellular Bone Microtissue Constructs through 3D Integrated Systems
Develop patient-specific multi-cellular bone constructs by co-culturing iPSC-derived MSCs, HSCs, and EPCs within 3D integrated platforms (microchip, hydrogel, and microparticle systems), and subsequently evaluate their in vivo efficacy and safety in bone defect models to enable the clinical translation of personalized bone regenerative therapy
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Establishing co-culture platforms for iEPC, iMSC, and iHSC to develop multi-cellular fusion bone constructs
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Developing a 3D high-efficiency cell differentiation fusion system through co-culture using hydrogel and microparticle technologies for optimized differentiation, along with selection of bone disease models
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Validating therapeutic efficacy and safety of patient-customized multi-cellular bone constructs in animal models through comprehensive evaluation including micro-CT, morphological, and histological analyses